"Aluminium is neurotoxic [11] and [23] and the concentrations of
aluminium found in these familial AD brains are unlikely to be benign
and indeed are highly likely to have contributed to both the onset and
the aggressive nature of any ongoing AD in these individuals. These data
lend support to the recent conclusion that brain aluminium will
contribute towards all forms of AD under certain conditions [15]."
The aluminium content of brain tissue donated by individuals with a
diagnosis of familial and probable familial Alzheimer’s disease was,
overall, extremely high. The mean aluminium data for each lobe across
all 12 donors are significantly higher (P < 0.05 in each case) than
equivalent data (using identical methods and quality assurance indices)
for the same lobes from a previous study which included 60 human brains
of which ca 60% had been diagnosed as sporadic Alzheimer’s disease [8]
and [12]. Herein we measured some of the highest values recorded for
individual samples of human brain tissue, for example to highlight just a
few, 11.54 μg/g in the occipital lobe of donor A2, 13.41 μg/g in the
frontal lobe of A5, 25.80 μg/g in the occipital lobe of A6, 35.65 μg/g
in the frontal lobe of A8 and 23.93 μg/g in the occipital lobe of A11
(Table 1).
