Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling : Nature Reviews Immunology : Nature Publishing Group
New from Nature Reviews Immunology. Developing B cells that have successfully expressed a pre-B cell receptor (pre-BCR) undergo clonal expansion, but must exit the cell cycle before rearranging their immunoglobulin light chain loci. The authors discuss how signalling through the interleukin-7 receptor and BCR is coordinated in a mutually exclusive manner to ensure the production of mature B cells without risking leukaemic transformation. (£) http://bit.ly/JydrmT